Hazard characterisations settings¶
Calculation settings¶
| Name | Description |
|---|---|
Risk type |
The type of exposure considered in the assessment; acute (short term) or chronic (long-term). |
Target level |
Select to express hazard characterisations at external or internal exposure level. |
Method |
Choose method for computing the hazard characterisations: from in-vivo or in-vitro points of departure or both. |
Expression type |
Specifies how hazard characterisations are expressed: as BMD, as NOAEL, or the expression type is ignored. |
Selection method in case of multiple candidate hazard characterisations |
Choose either the most toxic (default) or an aggregated hazard characterisation when in nominal runs there are multiple available candidates. In uncertainty runs, multiple candidates are always resampled. |
Impute missing hazard characterisations |
If selected, missing hazard characterisations are imputed based on Munro NOELs or on other available points of departure. |
Imputation method |
Imputation of Hazard characterisations: use low percentile (P5) or unbiased central estimate from either the Munro set or the available POD collection. |
Use BMDs from dose response models |
If selected, preferably BMDs from dose response models will be used. Only if these are not available, other POD data are used. |
Use inter-species conversions |
If selected, inter-species conversion factors ill be used (default value, e.g. 10, or data). |
Use intra-species factors |
If selected, intra-species conversion factors will be used (default value, e.g. 10, or data). |
Uncertainty settings¶
| Name | Description |
|---|---|
Resample intra-species factor |
Specifies whether intra-species factors are resampled from a parametric uncertainty distribution. |
Resample hazard characterisations or RPFs |
Specifies whether to resample the hazard characterisations or relative potency factors. Requires hazard characterisation or RPF uncertainty to be quantified in DoseResponseModelsUncertain or RelativePotencyFactorsUncertain tables. |