Available kinetic models

Physiologically based toxicokinetic (PBTK) models, or kinetic models for short, are mathematical representations of the animal or human body aimed at describing and predicting the time course distribution of chemicals in tissues and organs. Those internal dose metrics can usefully replace external exposure dose in the derivation of the quantitative dose-response relationships and following risk assessments. PBTK models can simulate both internal doses from exposure scenarios (forward dosimetry) and external dose from biomonitoring data (reverse dosimetry).

The following generic PBTK models are currently implemented in MCRA:

• EuroMix generic PBTK model [12].

• bisphenol model ETHZ [25].

Note

Additional kinetic models can be implemented, please contact the MCRA administrator.