Exposure response functions data formats

Download empty dataset template: Zipped CSV Excel

Exposure response functions

Accepted table names: ExposureResponseFunctions, ResponseFunctions, ExposureEffectFunctions.

Table 310 Table definition for Exposure response functions.
Name Type Description Aliases Required

idModel

AlphaNumeric (50)

The unique identifier of the exposure response model.

idModel, Model, ModelId

Yes

Name

AlphaNumeric (100)

Name of the exposure response model.

Name

No

Description

AlphaNumeric (200)

Additional description or label of the exposure response model.

Description

No

idSubstance

AlphaNumeric (50)

The substance code.

idSubstance, Substance, SubstanceId

Yes

idEffect

AlphaNumeric (50)

Code of the effect linked to this exposure response function.

idEffect, EffectId, Effect, EffectCode

Yes

TargetLevel

TargetLevelType

The target level. I.e., internal or external. If omitted, external is assumed.

TargetLevel, LevelTarget

No

ExposureRoute

AlphaNumeric (100)

The exposure route(s) (only applicable if exposure level is external) for which this exposure response function is defined.

ExposureRoute, Route

No

Biological matrix

BiologicalMatrix

The biological matrix (e.g., blood, urine) for which this exposure response function is defined.

BiologicalMatrix, MatrixSource, SourceMatrix

No

DoseUnit

DoseUnit

The unit of the result of the exposure response function.

DoseUnit, Unit

Yes

ExpressionType

ExpressionType

The expression type or adjustment method of the unit. This field specifies how the unit (target) is adjusted, e.g. for blood lipids for fat soluble biomarkers (‘mg/g lipids’) or the dilution level of the urine (‘mg/g creatinine’).

ExpressionType, AdjustmentMethod

No

Effect metric

EffectMetric

The type of risk for which this exposure response function is defined.

EffectMetric, ResponseMetric, Metric

Yes

ExposureResponseType

ExposureResponseType

The type of specification used to define the relation between the exposure and the exposure response.

ExposureResponseType, ErType, ErfType

Yes

ExposureResponseSpecification

AlphaNumeric (200)

The specification for the exposure response. Either a mathematical expression when the exposure response type is function, or a single value if the exposure response type is constant, perDoubling or perUnit.

ExposureResponseSpecification, ErfSpecification, ErSpecification

Yes

Baseline

Numeric (50)

Baseline level of the exposure response function.

Baseline

Yes

Exposure response function subgroups

Exposure response functions defined per exposure category.

Accepted table names: ErfSubgroups, ErfSubgroup.

Table 311 Table definition for Exposure response function subgroups.
Name Type Description Aliases Required

idModel

AlphaNumeric (50)

The unique identifier of the exposure response model.

idModel

Yes

idSubgroup

AlphaNumeric (50)

The unique identifier of the subgroup.

idSubgroup

Yes

ExposureUpper

Numeric (50)

Specifies the upper bound of the exposure percentile of the exposure response function subgroup. Exposure belong to a subgroup when the exposure is equal or lower than the specified upper bound and larger than the specified upper bound of the previous subgroup.

ExposureUpper, UpperExposure

No

ExposureResponseSpecification

AlphaNumeric (200)

The specification for the exposure response. Either a mathematical expression when the exposure response type is function, or a single value if the exposure response type is constant, perDoubling, or perUnit.

ErfSpecification, ExposureResponseSpecification, ExposureResponseFunctionSpecification

Yes

ExposureResponseSpecificationLower

AlphaNumeric (200)

Exposure response lower uncertainty bound. Either a mathematical expression when the exposure response type is function, or a single value if the exposure response type is constant, perDoubling, or perUnit.

ExposureResponseSpecificationLower, ErfLower

No

ExposureResponseSpecificationUpper

AlphaNumeric (200)

Exposure response upper uncertainty bound. Either a mathematical expression when the exposure response type is function, or a single value if the exposure response type is constant, perDoubling, or perUnit.

ExposureResponseSpecificationUpper, ErfUpper

No