Risk steatosis from imazalil

This standard action is of type: Risks

Traditional risk assessment often uses animal data to evaluate toxicological limit values, such as the acceptable daily intake (ADI). However, in-vitro tests may help to reduce the use of test animals. In the standard action described here such a traditional risk calculation can be compared to a similar calculation based on in-vitro data. For example, a risk calculation of steatosis as health effect and imazalil as chemical substance can be compared to the toxicological hazard characterisation based on in-vitro data from AdipoRed measurements in human liver cells. In-vitro concentrations are assumed to represent internal liver concentrations. A human physiologically based kinetic model for imazalil is used to extrapolate from in-vitro to in-vivo doses.

In this standard action, risk for steatosis from exposure to imazalil is estimated from in-vivo or in-vitro based hazard characterisations.

Two parameter sets are available:
  1. estimates based on QSAR models only, and

  2. estimates based on QSAR models and in-vitro experiments.

The latter parameter set shows that in the long term concentration levels of imazalil in the liver are stationary.

Table 280 Datasources for Risk steatosis from imazalil.
Table Group Name Repository Type

AdverseOutcomePathwayNetworks

AOPN-Effects-EffectRelations-181017.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed

Effects

AOPN-Effects-EffectRelations-181017.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed

DoseResponseData

BfR-HepaRG-AdipoRed-Single.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed

Concentrations

ConcentrationsSSD_20190129.zip

Standard Actions/Risk steatosis from imazalil

Fixed

Compounds

EuroMix Substances Inventory (v8) (PPPs).zip

Standard Actions/Risk steatosis from imazalil

Fixed

KineticModels

EuroMix-Cosmos_Tebby et al ParamA_QSAR.xlsx

Standard Actions/Risk steatosis from imazalil

Variable

KineticModels

Euromix-Cosmos_Tebby et al ParamB_QSAR_vitro.xlsx

Standard Actions/Risk steatosis from imazalil

Variable

UnitVariability

Foods coded in FoodEx1.mdb

Standard Actions/Risk steatosis from imazalil

Fixed

HazardCharacterisations

HazardCharacterisation Imazalil.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed

Survey

NL-VCP-RPC 2005-2006 2-6yr.mdb

Standard Actions/Risk steatosis from imazalil

Fixed

Survey

NL-VCP-RPC 2007-2010 7-69yr.mdb

Standard Actions/Risk steatosis from imazalil

Fixed

Survey

NL-VCP-RPC 2010-2012 70+yr.mdb

Standard Actions/Risk steatosis from imazalil

Fixed

FoodTranslations

NL-VCP-RPC Foods.mdb

Standard Actions/Risk steatosis from imazalil

Fixed

Foods

NL-VCP-RPC Foods.mdb

Standard Actions/Risk steatosis from imazalil

Fixed

EffectRepresentations

TestSystems-Responses-EffectRepresentations-181026.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed

Responses

TestSystems-Responses-EffectRepresentations-181026.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed

TestSystems

TestSystems-Responses-EffectRepresentations-181026.xlsx

Standard Actions/Risk steatosis from imazalil

Fixed